School of Medicine - Basic Medical ScienceAnatomy I



The unique leukemia inhibitory factor (LIF) signal pathway between mother and fetuses have been identified in rodents (Simamura et al., 2010). The maternal LIF signals induce adrenocorticotropic hormone (ACTH) from the placenta, which in turn induces LIF secretion from nucleated erythroblasts of fetuses. Finally, LIF of fetal origin contributes to the brain development and erythropoiesis. In our laboratory, details of the molecular mechanisms and its physiological functions have been extensively investigated. Then, we have investigated the interaction between an failure of this maternal-fetal signal relay of LIF and a risk of prenatal origin of autism, schizophrenia or bipolar disorder.
We have developed the new method for making biological specimens (brain, lung, intestine, other organs, whole embryos, etc.) transparent to observe the internal structures. Using this technique, details of GFP expressing cells in the deep area can be detected. Whole mount bone staining of small fishes (medaka, zebra fishes), frogs (Xenopus laebis) or mouse and rat fetuses are rapidly completed with this technique.

Contact Information

TEL: 076-218-8113 +81-76-218-8113 / FAX: 076-218-8189 +81-76-218-8189 / Email:


Professor and Chair

  • HATTA Toshihisa 八田


  • HIGASHI Nobuaki

Assistant Professor

  • SAKATA Hiromi
  • SHIMADA Hiroki

Senior Assistant Professor

  • TSUKADA Tsuyoshi
  • MASUDA Natsumi

Research Achievements

Research Activities

  • Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T.: Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1, 2 and 5. PLOS ONE. 2015 Apr 10(4):1-17. DOI: 10.1371/journal.pone.0123232
  • Tsukada T, Simamura E, Shimada H, Arai T, Higashi N, Akai T, Iizuka H, Hatta T.: The suppression of maternal-fetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in mice. PLOS ONE. 2015 (in press)
  • Inoue T1, Hashimoto R, Matsumoto A, Jahan E, Rafiq AM, Udagawa J, Hatta T, Otani H.: In vivo Analysis of Arg-Gly-Asp Sequence/Integrin α5β1-Mediated SignalInvolvement in Embryonic Enchondral Ossification by exo utero DevelopmentSystem. J Bone Miner Res. 2014 Jul; 29(7):1554-63. DOI: 10.1002/jbmr.2166. PMID:24375788 [PubMed - in process]
  • Yamada M, Udagawa J, Hashimato R, Matsumoto A, Hatta T, Otani H.: Interkinetic nuclear migration during early development of midgut and ureteric epithelia. Anat Sci Int. 88: 31-37 2012  査読有  DOI: 10.1007/s12565-012-0156-8
  • Simamura E, Shimada H, Higashi N, Uchishiba M, Otani H, Hatta T.: Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. Endocrinology 151: 1853-1862 2010  DOI: 10.1210/en.2009-0985

External Research Funding

  • Grant-in-Aid for Challenging Exploratory Research (15K15405)
  • Grant-in-Aid for Scientific Research (25293241)
  • Grant-in-Aid for Challenging Exploratory Research (24659512)
  • Grant-in-Aid for Scientific Research on Innovative Areas (23112006)
  • Grant-in-Aid for Scientific Research (22390216)